A super molecule that is only started becoming understood by scientists in the last few years. The difference between circRNA and other RNA is that the former take a circle. This special shape allows it to perform functions such as transporting essential materials that our body needs inside your cells, similar to the Yaohai's product like Microbial Biopharmaceutical Process Scale Up. What is fascinating scientists around the world lately, is that a novel type of circRNA has recently been found, called Reporter Gene circRNA — and its about to enlighten us on the mysteries of our bodies.
Where Reporter Gene circRNA meets the demand of scientists and provides a solution to this critical issue, just like the Recombinant Type III Collagen Production built by Yaohai. If a gene is being 'turned on' then it indicates that the cell is using that gene to produce protein. It functions something like a marker or flag for scientists to know when a gene is on: They can assess the presence of this specific circRNA. Professor Enrico Capobianco explained that a specific tag can be added to Reporter Gene circRNAs such that these tags will glow when the gene is turned on. This enables scientists to identify every gene turned on in various cells, potentially uncovering key insights into the way our body functions and processes to maintain health.
It will be very helpful for researchers studying diseases if they can use Reporter Gene circRNA that affects the level of expression of their target. Already, scientists are using it to understand how our cells do what they do and how diseases can arise. Cancer cells, for instance, tend to rely on different genes than healthy cells do to thrive and spread. Understanding the Reporter Gene circRNA in cancer cells increases our knowledge of how a cancer forms and discover new methods to cure this disease. It is particularly critical and a life-saving research.
The researchers suggest that in the future, Reporter Gene circRNA may be used to gain more insight into brain diseases as well, same with Yaohai's VLP Fermentation and Purification Process. The brain is an incredibly complex organ and there we are still many years away from ever understanding how it works. With Reporter Gene circRNA, researchers will be able to gain insight into how distinct brain regions of the brain exchange information. More about this knowledge can help treating such as memory and syphilis Parkinson, who move a lot from brain disease. Researchers can therefore learn about how Reporter Gene circRNA operates within the brain, in order to motivate others who are experiencing these conditions.
Recent scientific research is shedding light on many more associations of Reporter Gene circRNAs with a variety of diseases, just like the saRNA-LNP Encapsulation Protocol built by Yaohai. For instance, some research has suggested that malfunctioning Reporter Gene circRNA is involved in changing the way our bodies function in immune diseases — meaning conditions where our immune systems turn on ourselves (such as lupus). But another research point to the fact that circRNAs, can also be considered as a 'Reporter Gene' and are important in heart disease, they claim it is one of the hidden burden on mankind.
A reporter Gene circRNA is a cool molecule, we have discovered through the study into how our bodies work and can be modified to cure diseases, along with Yaohai's product Microbial Master Cell Bank. Over the past few years, scientists have identified a number of new ways to better study circRNA. One option to explore is a new technique called single-molecule RNA imaging, which some scientists are doing. This is a neat approach because it allows them to observe certain circRNAs being expressed within single cells. That provides researchers with a wealth of information, from how genes are controlled to how they respond to different situations.
Yaohai Bio-Pharma is experienced in biologicals derived from microbial sources. We provide customized RD solutions and manufacturing, while minimising potential risks. We have worked on various modalities, including recombinant subunit vaccines, peptides hormones, cytokines growth factors, single-domain antibodies enzymes, plasmid DNA various mRNAs, and more. We have specialized in multiple microorganisms, including Reporter Gene circRNA intracellular and extracellular secretion (yields up to 15g/L) and intracellular soluble bacteria and inclusion body (yields up to 10g/L). We have also established a BSL-2 fermentation platform to create bacteria-based vaccines. We are experts in improving processes, boosting product yields, and decreasing production costs. We have a highly efficient technology team that ensures timely and top-quality project delivery. This allows us to bring your unique products faster to market.
Yaohai BioPharma, a Reporter Gene circRNA Microbial CDMO, integrates regulatory affairs and quality management. We have a quality system that is compliant with current GMP standards, as well as regulations around the globe. Our regulatory team is knowledgeable in global regulatory frameworks to expedite biological launches. We make sure that production processes are traceable, high-quality products, and complying with the rules of the US FDA and EU EMA. Australia TGA and China NMPA is also fulfilled. Yaohai BioPharma has successfully passed the audit on site of the European Union's Qualified Person (QP) to ensure our GMP quality system and production site. We also have passed the initial certification audits of the ISO9001 Quality Management System and ISO14001 Environmental Management System.
Yaohai Bio-Pharma, a top 10 Reporter Gene circRNA of biological products, is a specialist in microbial fermentation. We have set up a modern facility that has robust RD capabilities and advanced infrastructure. Five lines of production for drugs conforming to GMP standards to purify and ferment microbial cells along with two fill and finish lines for vials as well as cartridges and needles pre-filled are readily available. The fermentation scales available for use range from 100L to 2000L. Filling specifications for vias are 1ml to 25ml, whereas pre-filled syringe or cartridge filling requirements are between 1-3ml. The production workshop is cGMP certified and offers the availability of commercial and clinical samples. The large molecules manufactured in our facility are available for delivery worldwide.
Yaohai Bio-Pharma is a leading in microbial biologics CDMO. Our primary focus is the production of microbial vaccinations and therapeutics for managing pets, human and Reporter Gene circRNA. We are equipped with cutting-edge RD platforms as well as manufacturing technologies that encompass the entire process beginning with the development of microbial strains and cell banking, to method and process development, to clinical and commercial manufacture that ensures the successful supply of new solutions. Through the years, we have accumulated vast knowledge of microbial-based bio processing. Over 200 projects have been successfully completed and we assist our clients to get through regulations, such as those of the US FDA and EU EMA. We also assist them in navigating Australia TGA and China NMPA. We are able respond promptly to market demands and offer tailored CDMO services thanks to our experience and expertise.