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Yeast: Key Player in VLP Vaccine for Polio

Sep 25, 2024

Poliomyelitis (polio) is caused by a virus, with symptoms including fever, upper respiratory discomfort, and limb paralysis. The disease is preventable but difficult to cure, and can easily lead to lifelong disability or even death. Thus, vaccines ar...

Marvelous Fermentation Rate Control Strategies
Sep 24, 2024
Microbial fermentation rate control aims to optimize growth conditions by precisely adjusting key factors such as temperature, pH, dissolved oxygen, and substrate concentration, ensuring that microorganisms are in their optimal physiological state. T...
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Pet's Dedicated Insulin Solution for a Sweet Life
Sep 23, 2024
Diabetes mellitus (DM) is a prevalent disease that affects not only humans but also our beloved pets. As pets' diets improve, their chances of developing diabetes increase due to higher rates of obesity. Based on the database encompassing 2.5 million...
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Harnessing the Power of Fed-batch Fermentation Strategy
Sep 20, 2024
Pichia pastoris is widely used in the production of various heterologous proteins. The High-Cell-Density Fermentation (HCDF) technology, implemented through Fed-Batch feeding, has successfully achieved large-scale production of biopharmaceuticals and...
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Conquering Hepatitis B with Yaohai
Sep 19, 2024
The World Health Organization (WHO) reports that annually, 1.5 million new cases of chronic hepatitis B infection emerge, affecting 296 million individuals globally. Hepatitis B is the disease that causes the most deaths after COVID-19. Therefore, we...
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Comparative Analysis of Yeast and E. coli in Release Testing
Sep 18, 2024
In the field of biopharmaceuticals, Escherichia coli (E. coli) and yeast are two widely used microbial expression systems that have addressed significant challenges such as industrialization and batch-to-batch stability of biological products. Levera...
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Do You Know the Groundbreaking Advancement in Insulin Technology?
Sep 14, 2024
Recombinant human insulin is a paradigmatic case of the mass production of genetically engineered drugs and a crucial application for microbial expression. Since its discovery a century ago, insulin medications have undergone continuous advancements,...
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The Application of VLPs in Human and Veterinary Vaccines
Sep 13, 2024
Last week, we briefly introduced the features, mechanisms of action (MoA), and expression systems of VLPs (Virus-like Particles). VLPs are viral structural proteins that do not contain viral genetic material. Besides, their advantages include nanosca...
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VLPs and Its Manufacturing Process
Sep 12, 2024
Virus-like Particles (VLPs) are unique biomaterials that have similar structures to viruses but essentially do not contain viral genetic material such as DNA or RNA. Therefore, VLPs wouldn't lead to infections in the human body. Due to this character...
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Methods to Improve the Yield of pDNA
Sep 11, 2024
The production of plasmid DNA (pDNA) relies on genetic recombination, which involves connecting the target gene and other elements to form a covalently closed circular structure. High cell-density fermentation of Escherichia coli and purification are...
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