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Explore the Fascinating World of the Lithium Chloride Precipitation
Explore the Fascinating World of the Lithium Chloride Precipitation
Oct 28, 2024

Lithium chloride precipitation is widely used for separating RNA from solution. Here's the breakdown of the process: 1. Sample preparation: Start with a sample containing RNA, such as in-vitro transcript mixture. 2. Lithium chloride addition: Add an...

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  • Recombinant Protein Production: Engineered E. coli Strains
    Recombinant Protein Production: Engineered E. coli Strains
    Oct 25, 2024

    Escherichia coli (E. coli) has played a significant role in producing recombinant proteins in the biopharmaceutical industry, serving as the first expression vector for manufacturing biological medicine. E. coli boasts rapid growth, convenient geneti...

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  • 2024 Updated mRNA Purification Methods
    2024 Updated mRNA Purification Methods
    Oct 23, 2024

    Purification, a crucial step in mRNA production, involves removing impurities such as unreacted chemicals or residual materials. The purification process ensures batch-to-batch consistency of mRNA and lipid nanoparticle (LNP) formulations, removing u...

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  • The Magic of P. pastoris: Shaping Recombinant Protein Production
    The Magic of P. pastoris: Shaping Recombinant Protein Production
    Oct 16, 2024

    Recombinant proteins, which are proteins expressed in host cells through genetic engineering techniques, have found widespread applications in biomedical research, therapy, and diagnostics. The selection of an appropriate expression system is a cruci...

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  • DNA Vaccine Production Scale-up Strategies
    DNA Vaccine Production Scale-up Strategies
    Oct 14, 2024

    Since the initial demonstration of gene expression in vivo through naked DNA injection, DNA vaccines, and gene therapies have advanced significantly. Plasmid DNA is used in both approaches to treat diseases by inducing protein expression. In comparis...

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  • Nanobodies Meet CAR-T: Shaping the Future of Cancer Therapy
    Nanobodies Meet CAR-T: Shaping the Future of Cancer Therapy
    Oct 10, 2024

    Chimeric Antigen Receptor T-cell (CAR-T) therapy is an emerging cellular immunotherapy that genetically modifies T-cells to express Chimeric Antigen Receptors (CARs) on their surfaces. These receptors enable T-cells to recognize and specifically targ...

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  • The Manufacturing Process and Applications of Nanobody
    The Manufacturing Process and Applications of Nanobody
    Oct 09, 2024

    By targeting specific viruses or structures, engineered antibodies can potentially treat certain high-risk populations. However, similar to monoclonal antibodies, their widespread application is hindered by the high production costs and their large s...

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  • Plasmid DNA: The Key to Unlocking Cancer's Therapy Code
    Plasmid DNA: The Key to Unlocking Cancer's Therapy Code
    Sep 27, 2024

    Recently, gene therapy has showcased the huge potential in cancer treatment. It can introduce exogenous normal genes into human target cells to repair, replace, or modulate genes within the patient, ultimately achieving therapeutic goals at the ...

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  • Polypeptides Drugs: The Future of Biomedicine
    Polypeptides Drugs: The Future of Biomedicine
    Sep 26, 2024

    The market for polypeptide drugs is experiencing rapid growth in the biomedical sector, with an annual compound growth rate of 8.5% globally from 2020 to 2030, expected to reach US$141.8 billion by 2030. Polypeptide drugs are produced via methods lik...

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  • Yeast: Key Player in VLP Vaccine for Polio
    Yeast: Key Player in VLP Vaccine for Polio
    Sep 25, 2024

    Poliomyelitis (polio) is caused by a virus, with symptoms including fever, upper respiratory discomfort, and limb paralysis. The disease is preventable but difficult to cure, and can easily lead to lifelong disability or even death. Thus, vaccines ar...

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  • Marvelous Fermentation Rate Control Strategies
    Marvelous Fermentation Rate Control Strategies
    Sep 24, 2024

    Microbial fermentation rate control aims to optimize growth conditions by precisely adjusting key factors such as temperature, pH, dissolved oxygen, and substrate concentration, ensuring that microorganisms are in their optimal physiological state. T...

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  • Pet's Dedicated Insulin Solution for a Sweet Life
    Pet's Dedicated Insulin Solution for a Sweet Life
    Sep 23, 2024

    Diabetes mellitus (DM) is a prevalent disease that affects not only humans but also our beloved pets. As pets' diets improve, their chances of developing diabetes increase due to higher rates of obesity. Based on the database encompassing 2.5 million...

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  • Harnessing the Power of Fed-batch Fermentation Strategy
    Harnessing the Power of Fed-batch Fermentation Strategy
    Sep 20, 2024

    Pichia pastoris is widely used in the production of various heterologous proteins. The High-Cell-Density Fermentation (HCDF) technology, implemented through Fed-Batch feeding, has successfully achieved large-scale production of biopharmaceuticals and...

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  • Conquering Hepatitis B with Yaohai
    Conquering Hepatitis B with Yaohai
    Sep 19, 2024

    The World Health Organization (WHO) reports that annually, 1.5 million new cases of chronic hepatitis B infection emerge, affecting 296 million individuals globally. Hepatitis B is the disease that causes the most deaths after COVID-19. Therefore, we...

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  • Comparative Analysis of Yeast and E. coli in Release Testing
    Comparative Analysis of Yeast and E. coli in Release Testing
    Sep 18, 2024

    In the field of biopharmaceuticals, Escherichia coli (E. coli) and yeast are two widely used microbial expression systems that have addressed significant challenges such as industrialization and batch-to-batch stability of biological products. Levera...

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  • Do You Know the Groundbreaking Advancement in Insulin Technology?
    Do You Know the Groundbreaking Advancement in Insulin Technology?
    Sep 14, 2024

    Recombinant human insulin is a paradigmatic case of the mass production of genetically engineered drugs and a crucial application for microbial expression. Since its discovery a century ago, insulin medications have undergone continuous advancements,...

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  • The Application of VLPs in Human and Veterinary Vaccines
    The Application of VLPs in Human and Veterinary Vaccines
    Sep 13, 2024

    Last week, we briefly introduced the features, mechanisms of action (MoA), and expression systems of VLPs (Virus-like Particles). VLPs are viral structural proteins that do not contain viral genetic material. Besides, their advantages include nanosca...

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  • VLPs and Its Manufacturing Process
    VLPs and Its Manufacturing Process
    Sep 12, 2024

    Virus-like Particles (VLPs) are unique biomaterials that have similar structures to viruses but essentially do not contain viral genetic material such as DNA or RNA. Therefore, VLPs wouldn't lead to infections in the human body. Due to this character...

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  • Methods to Improve the Yield of pDNA
    Methods to Improve the Yield of pDNA
    Sep 11, 2024

    The production of plasmid DNA (pDNA) relies on genetic recombination, which involves connecting the target gene and other elements to form a covalently closed circular structure. High cell-density fermentation of Escherichia coli and purification are...

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