Microbial CRDMO Solutions with excellence in quality and global regulatory compliance
Vaccine
Accelerate your pipeline with Yaohai Bio-Pharmas premier vaccine CDMO platform, delivering end-to-end vaccine development and manufacturing services from initial vaccine process development through to vaccine manufacturing with GMP compliance. Backed by our advanced microbial platform, we provide scalable solutions for vaccine modalities—including mRNA vaccine development, dna vaccine production, and VLP vaccines—as well as established platforms for subunit, toxoid, inactivated, and live-attenuated vaccines to ensure a smooth transition to commercial vaccine production.
Yaohai Bio-Pharma delivers high-yield vaccine development and manufacturing services utilizing advanced, scalable microbial fermentation systems based on E. coli and yeast.
Microbial Expression Systems
1. Genetic Vaccines
mRNA Vaccine
Comprehensive vaccine manufacturing and mrna vaccine development support, optimizing high-quality pDNA templates and scaling transcription via microbial systems.
DNA Vaccine
Robust dna vaccine production and dna vaccine development, offering high-purity plasmid DNA isolation and process optimization to ensure clinical and commercial scalability.
2. Protein/Peptide-based Vaccines
Subunit Vaccine
Advanced expression and purification platforms for recombinant subunit vaccine antigens, maximizing target protein yield and structural integrity.
Protein/Peptide-based Therapeutic Vaccine
Precision CDMO solutions for designed peptides and therapeutic vaccine candidate manufacturing to target specific oncology or chronic diseases.
Virus-like Particle (VLP) Vaccine
Scalable vlpvaccine assembly and purification services, leveraging microbial expression to produce non-infectious, high-immunogenicity virus-like particles.
3. Polysaccharide & Conjugate Vaccines
Polysaccharide Vaccine
High-efficiency bacterial fermentation and specialized purification technologies to extract purified bacterial polysaccharides.
Conjugate Vaccine
Expert conjugation services linking carrier proteins with polysaccharides to enhance stable, long-term immune responses.
4. Toxoid Vaccines
Toxoid Vaccine
Controlled cultivation and precise inactivation tech for bacterial toxins, delivering intermediates under strict GMP conditions.
5. Microbial-based Vaccines
Live Attenuated Vaccine
Specialized GMP biomanufacturing tracks for ensuring strict containment controls, verified strain stability, and high-yield cultivation..
Inactivated Vaccine
Validated inactivation processing and robust downstream purification for delivering maximum safety profiles and reproducible batch quality.
Microbial-vector Vaccine
Advanced fermentation and genetic stability management for engineered microbe-like bacteria utilized as specialized antigen delivery vehicles.
Viral Vector Vaccine
Scalable process optimization and regulatory-compliant production for modified viruses (e.g., adenovirus) used in targeted vector vaccine pipelines.
Service Platform
Accelerate your pipeline’s path to clinic with Yaohai Bio-Pharma’s fully integrated vaccine CDMO platform. We offer comprehensive, one-stop vaccine development and manufacturing solutions that seamlessly bridge the gap between early-stage discovery and market launch. By anchoring our core competencies in specialized vaccine process development, GMP compliant vaccine manufacturing, and strategic regulatory filing support, we guarantee an efficient, high-yield transition to full-scale commercial vaccine production.
Our Microbial Vaccine Manufacturing Process
Navigate your project with certainty through our integrated vaccine CDMO workflow. The diagram below illustrates our complete vaccine manufacturing process—from initial plasmid construction and rigorous cell banking, through scalable vaccine process development, to final GMP vaccine manufacturing for IND submissions and global commercial release.
One-Stop Vaccine CDMO & Manufacturing Solutions
As a dedicated vaccine manufacturing company, we provide an integrated vaccine development service. Our platform accelerates your project from early vaccine process development through clinical evaluation to full-scale commercial vaccine production.
Microbial Strain Development and Screening for High-Yield Vaccine Process Development
Microbial Cell Banking (PCB/MCB/WCB) for Reliable Vaccine Development and Manufacturing
Upstream Process Development for mRNA Vaccine Production & DNA Vaccine Development
Downstream Process Development for Purified Subunit Vaccine, Toxoid vaccine and VLP vaccine
Formulation Development Optimized for Inactivated vaccine & Live attenuated vaccines
GMP Vaccine Manufacturing of Clinical-Grade Drug Substances
Fill and Finish Services for Commercial Vaccine Production
Analytical and Testing for the Complete mRNA Vaccine Manufacturing Process and Traditional Platforms
Regulatory Affairs* & IND/BLA Submission Support for Global Vaccine CDMO Compliance
*Different types of vaccines are produced using different processes.
Service Highlights
End-to-End Vaccine Development and Manufacturing Lifecycle
Comprehensive vaccine development service spanning from early-stage R&D and pilot scale-up to commercial-scale GMP vaccine manufacturing.
Integrated timeline planning for process validation, ICH-compliant stability studies, and global regulatory filing.
Tailored, turnkey vaccine CDMO solutions engineered to accelerate timelines and reduce time-to-market for innovative pipelines.
Advanced Technological Platforms for Vaccine Process Development
Seamless tech transfer backed by standardized GMP workflows, ensuring high-yield, reproducible batches for early-stage vaccine projects.
Proven microbial expression capabilities across diverse modalities: mRNA vaccine development, dna vaccine production, VLP vaccines, as well as subunit, toxoid, inactivated, and live-attenuated vaccines.
Industry-Leading Expertise as a Premier Vaccine Manufacturing Company
Over a decade of deep-rooted expertise in microbial-based vaccine manufacturing, scaling up complex recombinant proteins and nucleic acids.
Highly specialized, dedicated teams for advanced formulation development, rigorous QC testing, and large-scale commercial vaccine production.
Proactive risk-assessment frameworks and tech-transfer protocols that ensure accelerated project timelines and strict cost control.
Global Regulatory Compliance & GMP Quality Assurance
In-depth regulatory expertise and proven tracks in vaccine-specific IND/NDA submission pathways worldwide.
Robust quality management systems aligned with global regulatory updates and international policy shifts (FDA, EMA, and NMPA).
Ready-to-submit, comprehensive regulatory documentation templates to guarantee flawless compliance and smooth audits. Yaohai Bio-Pharma vaccine development service team following global regulatory and compliance standards
Microbial Vaccine FAQs
What vaccine modalities can Yaohai Bio-Pharma support for process development and manufacturingAs a specialized vaccine manufacturing company, we leverage advanced microbial fermentation systems (E. coli and yeast) to provide comprehensive vaccine development and manufacturing services. Our platform fully supports next-generation modalities—including mRNA vaccine development, dna vaccine production, and VLP vaccines—as well as traditional antigen platforms such as subunit vaccine, toxoid vaccine, inactivated vaccines, and live-attenuated vaccines.Do your vaccine CDMO services comply with international regulatory standards for commercial vaccine production?Yes. Our state-of-the-art facilities operate under strict global compliance, aligning with FDA, EMA, and NMPA guidelines.We offer full-lifecycle vaccine CDMO solutions, supporting your pipeline from early-stage process development and analytical method validation through process scale-up and GMP compliant manufacturing for clinical and commercial use.What specific capabilities do you offer to accelerate the development of mRNA vaccines?For development of mRNA vaccines, our microbial CRDMO platform provides high-efficiency microbial strain development and screening, robust plasmid DNA (pDNA) template production, and scaled-up mRNA vaccine manufacturing process optimization. Our integrated vaccine development service ensures maximum purity, structural stability, and high yields from pilot scale to commercialization.How does your vaccine CDMO platform ensure reliable technology transfer and IP protection?As a pure-play CRDMO with no proprietary therapeutic pipeline, we eliminate potential IP conflicts at the source. Strict confidentiality agreements, clear IP ownership terms, and dedicated project teams ensure strong protection of client information. Robust data security systems and controlled facility access safeguard proprietary information throughout the project lifecycle.
Yaohai Bio-Pharma delivers tailored solutions for global clients, meeting diverse project requirements with excellence and efficiency.
Proven Project Excellence
Proven track record of over 100 successful projects, spanning preclinical studies and Phase I/II/III clinical trials, including US–China dual submissions and Australian regulatory filings.
Regulatory Compliance Assurance
A robust GMP-aligned quality system with standardized SOPs, fully compliant with global regulatory guidelines across the entire product lifecycle.
Expert Team Support
Powered by industry-leading scientists and cross-functional experts, our team delivers CRDMO projects with speed, precision, and deep technical insight.
